3. St. Regis Hotel Lobby Bar
Wet your whistle with the Golden Gate Mary (a Bloody Mary made with chili powder and tequila sure to curl the hair on your chest). Heave a sigh of contentment that you made a clean get-away from the fam, then cozy up by the modern fireplace to take the chill off in this elegant bar.
St. Regis Hotel, 125 3rd Street, SoMa (415-284-4000).