65 and sunny, or 55 and fogged in. That's the gamble when you stay in SF for Memorial Day Weekend.

But sunshine and hot weather are a sure bet when you head to Vegas for The Strip's biggest party weekend of the season.

Stay
Steve Wynn's Encore turns two this Memorial Day Weekend, making it the place to be if you're staying on The Strip. Your reservation gets you front-of-the-line VIP access to Encore Beach Club's weekend-long party featuring world-class DJs (Deadmau5, David Guetta), and hot (literally) girls dancing on shower poles.
From $301 per night. 3121 Las Vegas Blvd. South (702-770-7300). Beach Club Tickets $30-100 here

Enjoy sweeping views of the strip through your floor-to-ceiling windows at Aria. The adults-only pool scene at Liquid is slightly more low-pro than at the other hotels on the strip. But this secluded contemporary oasis is still conducive to getting your party on.
From $199 per night. 3730 S. Las Vegas Blvd. (702-359-7757)

Eat
Gorge on TJ-style tacos late night without stepping off the strip at Tacos El Gordo. Feeling a little too tipsy? We recommend the spicy, porky Adobada fries. Regardless of your degree of drunkenness, keep your head about you as you navigate their two-line ordering system. One's for carnitas only, the other is for all their other meats.
3049 S. Las Vegas Blvd. (702-641-8228)

Look — but don't touch — at Lavo's Bikini Brunch. This Saturday morning soiree mixes classy Champagne brunch selections (white polenta pancakes, lemon ricotta waffles) with house music and bikini-clad go-go dancers. Like we said, classy.
Sat 2-6p. 3325 S. Las Vegas Blvd. (702-791-1818)

Do
From trance to house to dubstep, just about every big-name DJ is in Vegas this weekend. Take your pick of Skrillex at Tryst, Deadmau5 at XS and Encore Beach Club, or Tiesto at XS and Surrender Nightclub.
Check out the MDW grid of who's spinning where.

With all that partying, there's a good chance you'll be feeling a little — off. Which is why you should hop aboard the Hangover Heaven bus for a mobile IV. After 45 minutes of doctor-approved therapy, you'll be ready to hit the next club.
Cruising the strip daily 8a-3p. $90-150 here.